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Total 29681 results found since Jan 2013.

Enhancing Mass Spectrometry-Based MHC-I Peptide Identification Through a Targeted Database Search Approach.
Abstract MHC-bound peptide ligands dictate the activation and specificity of CD8+ T- cells-based and thus are important for devising T-cell immunotherapies. In recent times, advances in mass spectrometry (MS) have enabled the precise identification of these peptides, wherein MS/MS spectra are compared against a reference proteome. Unfortunately, matching immunopeptide MS/MS to reference proteome databases is hindered by inflated search spaces attributed to the number of matches that need to be considered due to a lack of enzyme restriction. These large search spaces limit the efficiency with which MHC-I peptides a...
Source: Mol Biol Cell - August 2, 2019 Category: Molecular Biology Authors: Konda P, Murphy JP, Nielsen M, Gujar S Tags: Methods Mol Biol Source Type: research

Integrating Database Search and De Novo Sequencing for Immunopeptidomics with DIA Approach.
Abstract Identification of tumor-specific antigens (neoantigens) is needed for development of effective cancer immunotherapy and a good source for such antigens are the pools of HLA-bound peptides presented exclusively by the tumor cells. Mass spectrometry (MS) has evolved as the method of choice for the exploration of the human immunopeptidome (HLA class-I and class-II peptides). The key challenge is to deal with the low abundance of these peptides. Data-independent acquisition (DIA) technology promises to capture the low abundance data. However, the high number of fragments ions generated from multiple peptide p...
Source: Journal of Biomolecular Techniques : JBT - November 30, 2019 Category: Molecular Biology Authors: Shan P, Tran H Tags: J Biomol Tech Source Type: research

Chaos synchronization and Nelder-Mead search for parameter estimation in nonlinear pharmacological systems: Estimating tumor antigenicity in a model of immunotherapy
Publication date: Available online 19 June 2018 Source:Progress in Biophysics and Molecular Biology Author(s): Nikhil Pillai, Morgan Craig, Aristeidis Dokoumetzidis, Sorell L. Schwartz, Robert Bies, Immanuel Freedman In mathematical pharmacology, models are constructed to confer a robust method for optimizing treatment. The predictive capability of pharmacological models depends heavily on the ability to track the system and to accurately determine parameters with reference to the sensitivity in projected outcomes. To closely track chaotic systems, one may choose to apply chaos synchronization. An advantageous byproduct o...
Source: Progress in Biophysics and Molecular Biology - June 19, 2018 Category: Molecular Biology Source Type: research

Current studies of immunotherapy in head and neck cancer
ConclusionNumerous clinical trials are addressing the suitability and efficacy of immune checkpoint modulators in HNSCC with the predominant targets being the established immune checkpoint receptors PD‐1/PD‐L1 and CTLA‐4. Recently presented results have shown a survival benefit, a favorable safety profile and an extended duration of response in favor of using immune checkpoint modulation in R/M HNSCC.This article is protected by copyright. All rights reserved.
Source: Clinical Otolaryngology - May 2, 2017 Category: ENT & OMF Authors: Volkan Dogan, Thorsten Rieckmann, Adrian M ünscher, Chia‐Jung Busch Tags: Original Article Source Type: research

Database search engines and target database features impinge upon the identification of post ‐translationally cis‐spliced peptides in HLA class I immunopeptidomes
This article is protected by copyright. All rights reserved
Source: Proteomics - February 20, 2022 Category: Biochemistry Authors: Michele Mishto, Yehor Horokhovskyi, John A. Cormican, Xiaoping Yang, Steven Lynham, Henning Urlaub, Juliane Liepe Tags: TECHNICAL BRIEF Source Type: research

Cancers, Vol. 15, Pages 4245: Immunotherapy for Colorectal Cancer with High Microsatellite Instability: The Ongoing Search for Biomarkers
rnero Élez Microsatellite instability (MSI) is a biological condition associated with inflamed tumors, high tumor mutational burden (TMB), and responses to immune checkpoint inhibitors. In colorectal cancer (CRC), MSI tumors are found in 5% of patients in the metastatic setting and 15% in early-stage disease. Following the impressive clinical activity of immune checkpoint inhibitors in the metastatic setting, associated with deep and long-lasting responses, the development of immune checkpoint inhibitors has expanded to early-stage disease. Several phase II trials have demonstrated a high rate of pathological compl...
Source: Cancers - August 24, 2023 Category: Cancer & Oncology Authors: Ros Baraibar Saoudi Rodriguez Salv à Tabernero Élez Tags: Review Source Type: research

Immune Checkpoint Inhibitors in Triple Negative Breast Cancer: The Search for the Optimal Biomarker
Biomark Insights. 2022 Feb 22;17:11772719221078774. doi: 10.1177/11772719221078774. eCollection 2022.ABSTRACTTriple negative breast cancer (TNBC) is a high-risk and aggressive malignancy characterized by the absence of estrogen receptors (ER) and progesterone receptors (PR) on the surface of malignant cells, and by the lack of overexpression of human epidermal growth factor 2 (HER2). It has limited therapeutic options compared to other subtypes of breast cancer. There is now a growing body of evidence on the role of immunotherapy in TNBC, however much of the data from clinical trials is conflicting and thus, challenging fo...
Source: Biomarker Insights - February 28, 2022 Category: General Medicine Authors: Sadaf Qureshi Nancy Chan Mridula George Shridar Ganesan Deborah Toppmeyer Coral Omene Source Type: research